DNAJC15 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD78126A
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using DNAJC15 Polyclonal Antibody at dilution 1:40
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using DNAJC15 Polyclonal Antibody at dilution 1:40
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Overview

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Product Name
DNAJC15 Polyclonal Antibody
Catalog Number
RD78126A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of a J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. MCJ (methylation-controlled J protein), also known as HSD18, DNAJD1 or DNAJC15, is a 150 amino acid ubiquitously expressed single-pass membrane protein containing one J domain. Localizing to the golgi apparatus and only present in vertebrates, MCJ may be associated with increased chemotherapeutic resistance in ovarian cancer by inducing expression of the Mdr drug transporter and preventing intracellular drug accumulation.

Immunogen Information

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Immunogen
Recombinant protein of human DNAJC15
Swissprot
Q9Y5T4
Synonyms
Cell growth inhibiting gene 22 proteinCell growth-inhibiting gene 22 proteinDJC15DnaJ (Hsp40) homolog subfamily C member 15DNAJ domain containingDnaJ homolog subfamily C member 15DNAJC15DNAJD1GIG22HSD18MCJMethylation controlled J proteinMethyl
Gene Accession
BC010910

Applications

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Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

Research Areas

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