DNASE1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD86819A
Western blot analysis of extracts of various cell lines using DNASE1 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using DNASE1 Polyclonal Antibody at 1:1000 dilution.
Product Name
DNASE1 Polyclonal Antibody
Catalog Number
RD86819A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Immunogen Information
Immunogen
Recombinant fusion protein of human DNASE1
Gene ID
1773
Swissprot
P24855
Synonyms
DNASE1DNL1DRNI
Calculated MW
27kDa/30kDa/35kDa
Observed MW
31KDa/45KDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.