CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.
Immunogen Information
Immunogen
Recombinant fusion protein of human DNMT3A
Gene ID
1788
Swissprot
Q9Y6K1
Synonyms
DNMT3ADNMT3A2M.HsaIIIATBRSDNMT3A
Calculated MW
29kDa/50kDa/54kDa/57kDa/59kDa
Observed MW
60kDa
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1mg/mL
Storage Buffer
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Storage Instructions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.