DOK4 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD75550A
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DOK4 Polyclonal Antibody at dilution 1:50
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using DOK4 Polyclonal Antibody at dilution 1:50
Product Name
DOK4 Polyclonal Antibody
Catalog Number
RD75550A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Docking protein 4is aproteinthat in humans is encoded by theDOK4gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
Immunogen Information
Immunogen
Recombinant protein of human DOK4
Swissprot
Q8TEW6
Synonyms
docking protein 4Downstream of tyrosine kinase 4FLJ10488insulin receptor substrate 5IRS5
Gene Accession
BC001540
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas