The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11.
Immunogen Information
Immunogen
Synthetic peptide of human DSC2
Swissprot
Q02487
Synonyms
ARVD11Cadherin family member 2CDHF2Desmocollin 3Desmocollin-2Desmocollin-3Desmocollin2Desmosomal glycoprotein II and IIIDesmosomal glycoprotein IIDesmosomal glycoprotein II/IIIDesmosomal glycoprotein IIIDG2DGII/IIIDKFZp686I11137DSC 2DSC2DS
Gene Accession
NP_077740
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4