The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.
Immunogen Information
Immunogen
Full length fusion protein
Swissprot
O75319
Synonyms
Dual specificity phosphatase 11Dual specificity protein phosphatase 11DUS11DUSP11Phosphatase that interacts with RNA/RNP complex 1PIR1RNA/RNP complex 1 interactingRNA/RNP complex interacting phosphataseRNA/RNP complex-1-interacting phosphataseRNA
Gene Accession
BC000346
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-150, ELISA 1:2000-10000
Concentration
1.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4