The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
Immunogen Information
Immunogen
Recombinant protein of human DUSP12
Swissprot
Q9UNI6
Synonyms
Dual specificity phosphatase 12Dual specificity protein phosphatase 12Dual specificity tyrosine phosphatase YVH1DUS12DUSP 1DUSP 12DUSP1DUSP12Serine/threonine specific protein phosphataseTDSP4YVH 1YVH1YVH1 protein tyrosine phosphatase (S. cerev
Gene Accession
BC006286
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4