EGFR,also named as ERBB1,is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene resides on chromosome 7p12,encoding a 170 kDa membrane-associated glycoprotein. Recent studies have shown EGFR plays a critical role in cancer development and progression,including cell proliferation,apoptosis,angiogenesis,and metastatic spread. Mutations in this gene are associated with lung cancer.
Immunogen Information
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse EGFR
Swissprot
P00533
Synonyms
Avian erythroblastic leukemia viral (v erb b) oncogene homologCell growth inhibiting protein 40Cell proliferation inducing protein 61EGF REGFREGFREpidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog)Epide
Calculated MW
134 kDa
Observed MW
175 kDa
Applications
Reactivity
Human
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000
Concentration
1.3 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4