E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
Immunogen Information
Immunogen
Recombinant protein of human EID1
Swissprot
Q9Y6B2
Synonyms
21 kDa pRb associated protein21 kDa pRb-associated proteinC15orf3CBPChromosome 15 open reading frame 3CREBBP/EP300 inhibitor 1CREBBP/EP300 inhibitory protein 1CRI 1CRI1E1A like inhibitor of differentiationE1A-like inhibitor of differentiation 1
Gene Accession
NP_055150
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4