Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
Immunogen Information
Immunogen
Fusion protein of human ELF3
Swissprot
P78545
Synonyms
E74 like factor 3E74 like factor 3 ets domain transcription factorE74 like factor 3 ets domain transcription factor epithelial specificE74 like factor 3 ETS domain transcription factor serine box epithelial specificE74-like factor 3Elf3ELF3Epitheli