One member of the STAT family, Stat3, participates in a wide range of biological processes including nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation and oncogenesis. Many of these responses are triggered by the IL-6 family of cytokines, which transduce their vital signals through a common gp130 receptor chain . A novel Stat3-Interacting Protein, StIP1, contains 12 WD40 repeats, which mediate protein-protein interactions . StIP1 exhibits an affinity for members of the JNK family and may play a specific role in regulating Stat3 activation. Overexpression of StIP1 blocks Stat3 activation, nuclear translocation and Stat3-dependent induction of a reporter gene, suggesting that StIP1 regulates the ligand-dependent activation of Stat3, probably by serving as a scaffold protein that promotes the interaction between JNK and the Stat3 substrate.
Immunogen Information
Immunogen
Recombinant protein of human ELP2
Swissprot
Q6IA86
Synonyms
AU023723Elongation protein 2 homolog (S. cerevisiae)Elongator acetyltransferase complex subunit 2Elongator complex protein 2elongator protein 2ELP2ELP2Epl2FLJ10879SHINC 2SHINC-2SHINC2signal transducer and activator of transcription 3 interacti
Gene Accession
BC032553
Applications
Reactivity
Human,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4