The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Immunogen Information
Immunogen
Recombinant protein of human EMC8
Swissprot
O43402
Synonyms
C16orf2C16orf4COX4 neighborCOX4neighbor ofCOX4ALCox4nbCX4NBER membrane protein complex subunit 8FAM158Bfamily with sequence similarity 158member BNeighbor of COX4NOC4Protein FAM158B
Calculated MW
24 kDa
Gene Accession
BC001472
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4