This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.
Immunogen Information
Immunogen
Recombinant protein of human ENO1
Swissprot
P06733
Synonyms
2 phospho D glycerate hydro lyase2-phospho-D-glycerate hydro-lyaseAlpha enolaseAlpha enolase like 1Alpha-enolaseC myc promoter binding proteinC-myc promoter-binding proteinEC 4.2.1.11eno1ENO1L1ENOAEnolase 1 (alpha)Enolase 1 (alpha) like 1Enol
Calculated MW
47 kDa
Gene Accession
BC001810
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4