Epidermal growth factor receptor substrate 15-like 1is aproteinthat in humans is encoded by theEPS15L1gene. Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) By similarity. Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2.
Immunogen Information
Immunogen
Recombinant protein of human EPS15L1
Swissprot
Q9UBC2
Synonyms
EP15Repidermal growth factor receptor pathway substrate 15- ike 1Epidermal growth factor receptor substrate 15 like 1Epidermal growth factor receptor substrate 15-like 1epidermal growth factor receptor substrate EPS15REps15 related proteinEps15-rela
Calculated MW
94 kDa
Gene Accession
BC131590
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.1 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4