ERCC6L Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD75800A
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ERCC6L Polyclonal Antibody at dilution 1:30
Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ERCC6L Polyclonal Antibody at dilution 1:30
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using ERCC6L Polyclonal Antibody at dilution 1:30
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using ERCC6L Polyclonal Antibody at dilution 1:30
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Overview
Circle
Product Name
ERCC6L Polyclonal Antibody
Catalog Number
RD75800A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Circle
PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.
Immunogen Information
Circle
Immunogen
Recombinant protein of human ERCC6L
Swissprot
Q2NKX8
Synonyms
ATP dependent helicase ERCC6 likeATP-dependent helicase ERCC6-likeDNA excision repair protein ERCC 6 likeDNA excision repair protein ERCC-6-likeERC6LERCC 6LErcc6lExcision repair cross complementing rodent repair deficiency complementation group 6 l
Gene Accession
BC008808
Applications
Circle
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

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