Western Blot analysis of 293T cell and Human brain malignant glioma tissue, Mouse brain and Human hepatocellular carcinoma tissue using ERK1/2 Polyclonal Antibody at dilution of 1:550
Immunohistochemistry of paraffin-embedded Human thyroid cancer using ERK1/2 Polyclonal Antibody at dilution of 1:30
Immunohistochemistry of paraffin-embedded Human brain using ERK1/2 Polyclonal Antibody at dilution of 1:30
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human MAPK1/MAPK3
Swissprot
P28482,P27361
Synonyms
ERK1ERK2ERK1/2
Calculated MW
41/43 kDa
Gene Accession
NP_002736/NP_002737
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4