The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62.
Immunogen Information
Immunogen
Fusion protein of human ERLIN1
Swissprot
O75477
Synonyms
Band 7 23-211 Keo4 (Interim) similar to C.elegans proteinC10orf69chromosome 10 open reading frame 69Endoplasmic reticulum lipid raft-associated protein 1ER lipid raft associated 1Erlin 1Erlin-1ERLIN1ERLN1KE04KEO4OTTHUMP00000059425Protein KE0
Gene Accession
BC031791
Applications
Reactivity
Human, Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200, ELISA 1:5000-1:10000
Concentration
0.72 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
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