FADD Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD75171A
Western Blot analysis of Mouse spleen tissue and RAW264.7 cell using FADD Polyclonal Antibody at dilution of 1:550
Immunohistochemistry of paraffin-embedded Human colon cancer using FADD Polyclonal Antibody at dilution of 1:35
Immunohistochemistry of paraffin-embedded Human tonsil using FADD Polyclonal Antibody at dilution of 1:35
Product Name
FADD Polyclonal Antibody
Catalog Number
RD75171A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Immunogen Information
Immunogen
Recombinant protein of human FADD
Swissprot
Q13158
Synonyms
FADDFADD proteinFADDFas (TNFRSF6) associated via death domainFas associated via death domainFas associating death domain containing proteinFas associating proteinFas associating protein with death domainFas TNFRSF6 associated via death domainFAS-
Calculated MW
23 kDa
Gene Accession
BC000334
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:5000, IHC 1:50-1:100
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas