FAM107B is a 131 amino acid protein that is encoded by a gene that maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious.
Immunogen Information
Immunogen
Recombinant protein of human FAM107A
Swissprot
O95990
Synonyms
Down regulated in renal cell carcinoma 1Down-regulated in renal cell carcinoma 1Downregulated in renal cell carcinomaDRR1F107AFAM107AFamily with sequence similarity 107member AFLJ30158FLJ45473Protein FAM107AProtein TU3ATU3A
Gene Accession
BC010561
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4