This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Synthetic peptide of human FBXO31
Swissprot
Q5XUX0
Synonyms
DKFZp434B027DKFZp434J1815F box only protein 31F box protein 31F-box only protein 31FBX14FBX31FBX31FBXO14Fbxo31FLJ22477MGC15419MGC9527pp2386Putative breast cancer tumor suppressorSCF ubiquitin ligase specificity factor
Gene Accession
NP_079011
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4