The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
Immunogen Information
Immunogen
Recombinant Rat Fibrinogen beta chain protein
Gene ID
24366
Swissprot
P14480
Synonyms
Beta fibrinogenEpididymis Secretory Sperm Binding Protein Li 78pFGBFibrinogen beta chainHEL-S-78p