This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Immunogen Information
Immunogen
Synthetic peptide of human FGR
Swissprot
P09769
Synonyms
c fgrc fgr protooncogenec src 2 proto oncogenec src2FgrFGRFLJ43153Gardner Rasheed feline sarcoma viral (v fgr)Gardner Rasheed feline sarcoma viral (v fgr) oncogene homologGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologMGC75096p55