This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Immunogen Information
Immunogen
Recombinant protein of human FHL2
Swissprot
Q14192
Synonyms
AAG 11AAG11Aging associated gene 11Down regulated in rhabdomyosarcoma LIM proteinDownregulated in rhabdomyosarcoma LIM proteinDRALFHL 2FHL-2Fhl2FHL2 proteinFHL2Four and a half LIM domain protein 2Four and a half LIM domains 2Four and a half L
Calculated MW
32 kDa
Gene Accession
NP_963849
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:5000, IHC 1:100-1:300
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4