Staining of normal human peripheral blood cells with APC Anti-Human CD3 Antibody and FITC Anti-Human CD43 Antibody[HI161] (left) or FITC Mouse IgG1, κ Isotype Control (right). Cells in the lymphocytes gate were used for analysis.
CD43, also known as Ly-48, leukosialin, sialophorin, leukocyte sialoglycoprotein, and W3/13, is a large single chain, type I transmembrane glycoprotein with abundant O-glycosylation and sialylation sites. It has been reported that CD43 binds to CD54 and Siglec-1. CD43 plays dual roles in cell adhesion and anti-adhesion as well as costimulation of T cell activation and survival, and induction of apoptosis of T cells and hematopoietic progenitors.