This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human FLNC
Swissprot
Q14315
Synonyms
ABPLActin binding like proteinFIlamin 2Filamin CFLN2Gamma filamin