FOXO1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD70351A
Immunohistochemistry analysis of paraffin-embedded human lung cancer using FOXO1 Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded Mouse kidney using FOXO1 Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded rat brain using FOXO1 Polyclonal Antibody at dilution of 1:300.
Product Name
FOXO1 Polyclonal Antibody
Catalog Number
RD70351A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
FOXO1,also named as FOXO1A,FKHR and FKH1,is a member of the FOXO subfamily of Forkhead transcription factors. FOXO1 is a transcription factor which acts as a regulator of cell responses to oxidative stress. FOXO1 interacts with LRPPRC and SIRT1. In the presence of KIRT1,FOXO1 mediates down-regulation of cyclin D1 and up-regulation of CDKN1B levels which are required for cell transition from proliferative growth to quiescence. FOXO1 contains three predicted protein kinase B phosphorylation sites (Thr-24,Ser-256,and Ser-319) that are conserved in other FOXO proteins. The t(2;13) and the variant t(1;13) translocations generate PAX3/FKHR and PAX7/FKHR fusion proteins respectively. The resulting protein is a transcriptional activator. Defects in FOXO1 are a cause of rhabdomyosarcoma type 2 (RMS2).
Immunogen Information
Immunogen
Recombinant protein corresponding to Mouse FOXO1
Swissprot
Q12778,Q9R1E0,G3V7R4
Synonyms
FKH 1FKH1FKHRForkhead (Drosophila) homolog 1 (rhabdomyosarcoma)Forkhead box O1Forkhead box protein O1Forkhead box protein O1AForkhead in rhabdomyosarcomaForkheadDrosophilahomolog ofin rhabdomyosarcomaFoxO transcription factorfoxo1FOXO1FOXO1
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC
Conjugation
Unconjugated
Dilution
IHC 1:300-1:1000
Concentration
320 μg/mL
Storage Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.