This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
Immunogen Information
Immunogen
Fusion protein of human FUS
Swissprot
P35637
Synonyms
75 kDa DNA pairing protein75 kDa DNA-pairing proteinALS6Amyotrophic lateral sclerosis 6fusFUS CHOPFus like proteinFUSFUS1Fused in sarcomaFusion (involved in t(12;16) in malignant liposarcoma)Fusion derived from t(12;16) malignant liposarcomaFu
Gene Accession
BC000402
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:30-150, ELISA 1:2000-10000
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4