This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2).
Immunogen Information
Immunogen
Fusion protein of human FYCO1
Swissprot
Q9BQS8
Synonyms
CATC2CTRCT18DKFZp779K1152FLJ13335FYCO1FYCO1FYVE and coiled coil domain containing 1FYVE and coiled coil domain containing protein 1FYVE and coiled-coil domain-containing protein 1MGC126517MGC126519RUFY3RUN and FYVE domain containing 3ZFYVE7Z