FZD6 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD80418A
Western blot analysis of extracts of various cell line using FZD6 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of various cell line using FZD6 Polyclonal Antibody at dilution of 1:1000.
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Overview

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Product Name
FZD6 Polyclonal Antibody
Catalog Number
RD80418A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit

Background

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This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

Immunogen Information

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Immunogen
Recombinant fusion protein of human FZD6 (NP_003497.2).
Gene ID
8323
Swissprot
O60353
Synonyms
FZD6FZ-6FZ6HFZ6NDNC10
Calculated MW
75 kDa/79 kDa
Observed MW
79 kDa

Applications

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Reactivity
Mouse,Rat
Tested Applications
WB
Conjugation
Unconjugated
Dilution
WB 1:1000-1:2000
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

Research Areas

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