This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene
Immunogen Information
Immunogen
Synthetic peptide of human GABRA1
Swissprot
P14867
Synonyms
ECA4EIEE19EJMEJM5Gaba receptor alpha 1 polypeptideGABA(A) receptorGABA(A) receptor subunit alpha 1GABA(A) receptor subunit alpha-1GABA(A) receptoralpha 1GABRA 1GABRA1Gamma aminobutyric acid (GABA) A receptor alpha 1Gamma aminobutyric acid A r
Calculated MW
52 kDa
Gene Accession
NP_000797
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4