GDNF family receptor alpha-3 is a protein that in humans is encoded by the GFRA3 gene. The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression.
Immunogen Information
Immunogen
Synthetic peptide of human GFRA3
Swissprot
O60609
Synonyms
GDNF family receptor alpha 3GDNF family receptor alpha-3GDNF receptor alpha-3GDNFR-alpha-3GDNFR3GFR-alpha-3GFRA3GFRA3Glial cell line derived neurotrophic factor receptor alpha 3GPI linked receptorOTTHUMP00000159486OTTHUMP00000224020
Calculated MW
44 kDa
Gene Accession
NP_001487
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,ELISA
Conjugation
Unconjugated
Dilution
WB 1:1000-1:3000
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4