This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance.
Immunogen Information
Immunogen
Recombinant protein of human NR3C1
Swissprot
P04150
Synonyms
GCCRGCRGCRGCRSTglucocorticoid nuclear receptor variant 1Glucocorticoid receptorGRGRLGrl1nr3c1Nuclear receptor subfamily 3 group C member 1nuclear receptor subfamily 3group Cmember 1 (glucocorticoid receptor)
Gene Accession
BC015610
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4