The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Recombinant Human Transmembrane glycoprotein NMB protein
Gene ID
10457
Swissprot
Q14956
Synonyms
Glycoprotein nmbGlycoprotein nmb like proteinGpnmbHGFINNMBOsteoactivinTransmembrane glycoproteinTransmembrane glycoprotein HGFINTransmembrane glycoprotein NMB