This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells.
Immunogen Information
Immunogen
Synthetic peptide of human GPR153
Swissprot
Q6NV75
Synonyms
DKFZp762B2210G Protein Coupled Receptor 153G Protein Coupled Receptor LS19072G protein coupled receptor PGR1G-protein coupled receptor PGR1GP153Gpr153PGR1Probable G-protein coupled receptor 153