This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Synthetic peptide of human GRIN2A
Swissprot
Q12879
Synonyms
EPNDFESDGluN2AGlutamate [NMDA] receptor subunit epsilon-1Glutamate receptorGlutamate receptor ionotropic N methyl D aspartate 2AGRIN 2AGRIN2AhNR2ALKSN methyl D aspartate receptor channelsubunit epsilon 1N Methyl D Aspartate Receptor Subtype 2A
Gene Accession
NP_000824
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:25-100, ELISA 1:2000-5000
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4