Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity.
Immunogen Information
Immunogen
Recombinant protein of human GSTA3
Swissprot
Q16772
Synonyms
Glutathione S alkyltransferase A3Glutathione S aralkyltransferase A3Glutathione S aryltransferase A3Glutathione S transferase A3 3Glutathione S transferase A3glutathione S transferase A3 subunitGlutathione S transferase alpha 3Glutathione S transfe
Calculated MW
25 kDa
Gene Accession
BC020619
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:25-1:100
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4