HBG1/HBG2 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD218774A
Western blot analysis of Human plasma solution using HBG1:HBG2 Polyclonal Antibody at dilution of 1:250
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using HBG1:HBG2 Polyclonal Antibody at dilution of 1:70(×200)
Product Name
HBG1/HBG2 Polyclonal Antibody
Catalog Number
RD218774A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Immunogen Information
Immunogen
Fusion protein of human HBG1/HBG2
Swissprot
P69891,P69892
Synonyms
A gamma globinG gamma globinGamma 1 globinGamma 2 globinGamma A hemoglobinGamma globinHb F AgammaHb F GgammahbfagammahbfggammaHBG 1HBG 2HBG1HBG2HBGAHBGRHemoglobin gamma 1 chainHemoglobin gamma 2 chainHemoglobin gamma AHemoglobin gamma
Calculated MW
16 kDa
Observed MW
Refer to figures
Gene Accession
BC010914
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas