Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors.
Immunogen Information
Immunogen
Recombinant protein of human HDAC8
Swissprot
Q9BY41
Synonyms
CDA07CDLS5HD 8HD8HDAC 8Hdac8HDAC8HDACL 1HDACL1Histone deacetylase 8Histone deacetylase like 1MRXS6RPD 3RPD3WTS
Calculated MW
42 kDa
Gene Accession
BC050433
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4