The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Immunogen Information
Immunogen
Synthetic peptide of human HMGCS2
Swissprot
P54868
Synonyms
3 hydroxy 3 methylglutaryl Coenzyme A synthase 2 (mitochondrial)3 hydroxy 3 methylglutaryl Coenzyme A synthase 23 hydroxy 3 methylglutaryl coenzyme A synthase3-hydroxy-3-methylglutaryl coenzyme A synthaseHMCS2HMG CoA synthaseHMG-CoA synthaseHMGCS 2
Calculated MW
57 kDa
Gene Accession
NP_005509
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:100-1:300
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4