In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.
Immunogen Information
Immunogen
Synthetic peptide of human HOXA7
Swissprot
P31268
Synonyms
ANTPAntpDrosophilahomolog ofHomeobox 1AHomeobox A7Homeobox protein Hox 1.1Homeobox protein Hox A7Homeobox protein Hox-1AHomeobox protein Hox-A7HOX1HOX1.1HOX1.1mousehomolog ofHox1AHOXA7HXA7OTTHUMP00000024835