HSD11B1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD252192A
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using HSD11B1 Polyclonal Antibody at dilution of 1:70(×200)
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using HSD11B1 Polyclonal Antibody at dilution of 1:70(×200)
Product Name
HSD11B1 Polyclonal Antibody
Catalog Number
RD252192A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Immunogen Information
Immunogen
Fusion protein of human HSD11B1
Swissprot
P28845
Synonyms
11 beta HSD 111 beta HSD111 beta hydroxysteroid dehydrogenase 111 DH11-beta hydroxysteroid dehydrogenasetype 111-beta-HSD111-beta-hydroxysteroid dehydrogenase 111-DH11DHCorticosteroid 11 beta dehydrogenase isozyme 1Corticosteroid 11-beta-dehydr
Gene Accession
BC012593
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200, ELISA 1:5000-1:10000
Concentration
1.2 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas