There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.
Immunogen Information
Immunogen
Synthetic peptide of human HSD11B2
Swissprot
P80365
Synonyms
11 beta HSD211 beta hydroxysteroid dehydrogenase type 211 DH211-beta-HSD211-beta-hydroxysteroid dehydrogenase type 211-DH2AMEAME1Corticosteroid 11 beta dehydrogenase isozyme 2Corticosteroid 11-beta-dehydrogenase isozyme 2DHI2HSD11B2HSD11KHSD2
Gene Accession
NP_000187
Applications
Reactivity
Human
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.6 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4