HSD17B1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Western Blot analysis of Human placenta tissue using HSD17B1 Polyclonal Antibody at dilution of 1:700
Immunohistochemistry of paraffin-embedded Human thyroid cancer using HSD17B1 Polyclonal Antibody at dilution of 1:40
Immunohistochemistry of paraffin-embedded Human brain using HSD17B1 Polyclonal Antibody at dilution of 1:40
Product Name
HSD17B1 Polyclonal Antibody
Catalog Number
RD76884A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy.
Immunogen Information
Immunogen
Synthetic peptide of human HSD17B1
Swissprot
P14061
Synonyms
17 beta HSD 117 beta hydroxysteroid dehydrogenase type 117-beta-HSD 117-beta-hydroxysteroid dehydrogenase type 120 alpha-hydroxysteroid dehydrogenase20-alpha-HSDDHB1E17KSRE2DHEDH17B1EDH17B2EDHB17Estradiol 17 beta dehydrogenase 1Estradiol 17-b
Calculated MW
35 kDa
Gene Accession
NP_000404
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.9 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas