HUWE1 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using HUWE1 Polyclonal Antibody at dilution of 1:30(×200)
Immunohistochemistry of paraffin-embedded Human lung cancer tissue using HUWE1 Polyclonal Antibody at dilution of 1:30(×200)
Product Name
HUWE1 Polyclonal Antibody
Catalog Number
RD219540A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit
Background
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation.
Immunogen Information
Immunogen
Synthetic peptide of human HUWE1
Swissprot
Q7Z6Z7
Synonyms
ARF binding protein 1ARF BP1ARF-binding protein 1ARF-BP1BJ-HCC-24 tumor antigenE3 ubiquitin protein ligase HUWE1E3 ubiquitin-protein ligase HUWE1HECTHECT domain protein LASU1HECT UBA and WWE domain containing protein 1HectH9Homologous to E6AP c
Gene Accession
NP113584
Applications
Reactivity
Human, Mouse, Rat
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:10-1:50, ELISA 1:5000-1:10000
Concentration
0.8 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas