Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence.
Immunogen Information
Immunogen
Recombinant protein of human IDH1
Swissprot
O75874
Synonyms
Cytosolic NADP isocitrate dehydrogenaseCytosolic NADP-isocitrate dehydrogenaseEpididymis luminal protein 216Epididymis secretory protein Li 26HEL-216HEL-S-26ICDHIDCDIDHIDH1IDHCIDPIDPCIsocitrate dehydrogenase (NADP(+)) 1 cytosolicIsocitrate d
Calculated MW
47 kDa
Gene Accession
BC012846
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000, IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4