This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
Immunogen Information
Immunogen
Recombinant protein of human IKZF3
Swissprot
Q9UKT9
Synonyms
AIOAiolosIKAROS family zinc finger 3 (Aiolos)IKAROS family zinc finger 3Ikaros family zinc finger protein 3IKZF 3IKZF3IKZF3zinc finger DNA binding protein AiolosZinc finger protein AiolosZinc finger protein subfamily 1A 3 (Aiolos)Zinc finger pr
Gene Accession
BC032707
Applications
Reactivity
Human,Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200
Concentration
0.7 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4