INS Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD267409A
Immunohistochemistry of paraffin-embedded Rat pancreatic islet using INS Polyclonal Antibody at dilution of 1:50 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse pancreatic islet using INS Polyclonal Antibody at dilution of 1:50 (40x lens).
Immunofluorescence analysis of Rat pancreas using INS Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of Mouse pancreas using INS Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.
Product Name
INS Polyclonal Antibody
Catalog Number
RD267409A
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Recombinant fusion protein of human INS (NP_000198.1).
Gene ID
3630
Swissprot
P01308
Synonyms
IDDMIDDM1IDDM2ILPRIRDNMODY10INSInsulininsulin
Applications
Reactivity
Human,Mouse,Rat
Tested Applications
IHC,IF
Conjugation
Unconjugated
Dilution
IHC 1:50-1:200 IF 1:50-1:200
Concentration
1 mg/mL
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.