IPO4 Polyclonal Antibody
For reference only. Please follow the manual included in your kit for instructions.
Catalog Number
RD75915A
Western Blot analysis of Hela cell and Human testis tissue, A549, Jurkat and K562 cell using IPO4 Polyclonal Antibody at dilution of 1:550
Immunohistochemistry of paraffin-embedded Human colon cancer using IPO4 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human prostate cancer using IPO4 Polyclonal Antibody at dilution of 1:50
Product Name
IPO4 Polyclonal Antibody
Catalog Number
RD75915A
Clonality
Polyclonal
Purification Method
Affinity purification
Isotype
IgG
Host
Rabbit
Background
Importin-4is aproteinthat in humans is encoded by theIPO4gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
Immunogen Information
Immunogen
Recombinant protein of human IPO4
Swissprot
Q8TEX9
Synonyms
Imp4Imp4bImportin 4Importin 4bImportin-4Importin-4bIpo4IPO4Ran binding protein 4Ran-binding protein 4RanBP4
Calculated MW
119 kDa
Gene Accession
BC003690
Applications
Reactivity
Human,Mouse
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Concentration
0.3 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.
Research Areas