This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.
Immunogen Information
Immunogen
Synthetic peptide of human ITGA2
Swissprot
P17301
Synonyms
BRCD 49bCD49 antigen like family member BCD49 antigen-like family member BCD49bCD49b antigenCollagen receptorDX5Glycoprotein Ia deficiency includedGP IaGP Ia deficiencyincludedGPIaHPA 5 includedHPA5 includedHuman platelet alloantigen system
Calculated MW
129 kDa
Gene Accession
NP_002194
Applications
Reactivity
Human
Tested Applications
WB,IHC,ELISA
Conjugation
Unconjugated
Dilution
WB 1:200-1:1000, IHC 1:25-1:100
Concentration
0.4 mg/mL
Storage Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4