ITGA8 Polyclonal Antibody

For reference only. Please follow the manual included in your kit for instructions.

Catalog Number
RD253512A
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue  using ITGA8 Polyclonal Antibody at dilution of 1:30(×200)
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using ITGA8 Polyclonal Antibody at dilution of 1:30(×200)
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Overview

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Product Name
ITGA8 Polyclonal Antibody
Catalog Number
RD253512A
Clonality
Polyclonal
Purification Method
Antigen affinity purification
Isotype
IgG
Host
Rabbit

Background

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Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms.

Immunogen Information

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Immunogen
Synthetic peptide of human ITGA8
Swissprot
P53708
Synonyms
Integrin alpha 8Integrin alpha-8 heavy chainIntegrin alpha-8 light chainITA8ITGA 8ITGA8
Gene Accession
NP003629

Applications

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Reactivity
Human, Mouse
Tested Applications
IHC,ELISA
Conjugation
Unconjugated
Dilution
IHC 1:25-1:100, ELISA 1:5000-1:10000
Concentration
0.5 mg/mL
Storage Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instructions
Store at -20°C. Avoid freeze / thaw cycles.

Research Areas

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